Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Nebulizer possibilities and limitations.

H Matthys1

  • 1Department of Pneumology, University Hospital Freiburg, Germany.

Journal of Aerosol Medicine : the Official Journal of the International Society for Aerosols in Medicine
|March 4, 1992
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of the effect of pharmacotherapy in common cold/acute bronchitis - the Bronchitis Severity Scale (BSS).

Pneumologie (Stuttgart, Germany)·2014
Same author

Symbols, abbreviations and units.

The European respiratory journal·2014
Same author

Positioning of the Bronchitis Severity Score (BSS) for standardised use in clinical studies.

Current medical research and opinion·2013
Same author

Efficacy and tolerability of EPs 7630 tablets in patients with acute bronchitis: a randomised, double-blind, placebo-controlled dose-finding study with a herbal drug preparation from Pelargonium sidoides.

Current medical research and opinion·2010
Same author

Treatment of acute bronchitis with a liquid herbal drug preparation from Pelargonium sidoides (EPs 7630): a randomised, double-blind, placebo-controlled, multicentre study.

Current medical research and opinion·2007
Same author

Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children.

Phytomedicine : international journal of phytotherapy and phytopharmacology·2006
Same journal

ASTRA Satellite Symposium -"The Importance of Size".

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosols for Medical Applications (GAeF Satellite Meeting).

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Mucus and cilia symposium.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Aerosol delivery systems.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Standardization.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
Same journal

Modeling.

Journal of aerosol medicine : the official journal of the International Society for Aerosols in Medicine·2009
See all related articles

The phase-out of chlorofluorocarbon (CFC) propellants in metered dose inhalers (MDIs) has spurred innovations in aerosol drug delivery, including new inhaler types and nebulizers for improved lung deposition.

Area of Science:

  • Respiratory Medicine
  • Pharmaceutical Technology
  • Drug Delivery Systems

Background:

  • The transition away from chlorofluorocarbon (CFC) propellants in metered dose inhalers (MDIs) necessitates the exploration of alternative aerosol delivery technologies.
  • Efficient drug delivery to the lungs is crucial for treating respiratory diseases.

Purpose of the Study:

  • To review the innovations and alternatives in aerosol drug delivery devices following the ban of CFC propellants in MDIs.
  • To discuss factors influencing the selection of appropriate aerosol delivery devices for patient care.

Main Methods:

  • Review of current and emerging aerosol delivery technologies, including non-CFC MDIs, nebulizers, and dry powder inhalers (DPIs).
  • Analysis of considerations for device selection, such as drug properties, medical needs, patient factors, and market availability.

Related Experiment Videos

Main Results:

  • Several alternatives to CFC-based MDIs have emerged, including new propellant MDIs, battery-driven nebulizers, pocket nebulizers, and self-actuated DPIs.
  • Device choice depends on drug formulation (powder vs. droplet), medical indication, patient cooperation, and economic factors.
  • Bronchial circulation plays a key role in the distribution of aerosolized medications within the lungs.

Conclusions:

  • The post-CFC era offers diverse aerosol delivery options, enhancing treatment possibilities for respiratory conditions.
  • Optimizing device selection based on a multifactorial approach ensures effective and patient-centered aerosol therapy.
  • Understanding lung pharmacokinetics, including bronchial circulation, is vital for maximizing therapeutic outcomes.