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Arterial substitutes in peripheral vascular surgery: a review
1Division of Vascular Surgery, Oregon Health Sciences University, Portland, 97201, USA.
Journal of Long-Term Effects of Medical Implants
|December 9, 1994
Summary
Vascular surgery relies on arterial substitutes for treating arterial disease. While prosthetic grafts and autogenous veins are effective, no perfect substitute exists, and all carry risks.
Area of Science:
- Vascular Surgery
- Biomaterials Science
- Regenerative Medicine
Background:
- Arterial disease management heavily relies on effective arterial substitutes.
- Advances in vascular surgery are intrinsically linked to the development of these substitutes.
- Current practice differentiates between prosthetic grafts for large arteries and autogenous veins for smaller vessels.
Purpose of the Study:
- To review existing and current arterial substitutes used in general vascular surgery.
- To highlight the clinical significance and limitations of various arterial substitutes.
- To underscore the absence of a perfect arterial substitute in current practice.
Main Methods:
- Literature review of basic research and clinical experience with arterial substitutes.
- Analysis of the clinical utility of prosthetic grafts and autogenous veins.
- Examination of complications associated with implanted arterial substitutes.
Main Results:
- Prosthetic grafts are preferred for large-caliber artery replacement.
- Autogenous veins are optimal for small, low-flow vessels in extremities.
- All currently used arterial substitutes are associated with known short- and long-term complications.
Conclusions:
- The ideal arterial substitute remains elusive in vascular surgery.
- Clinical application of current arterial substitutes necessitates careful consideration of their inherent risks.
- Ongoing research is crucial for developing safer and more effective arterial substitutes.