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Trace elements in pediatrics.

G Lockitch1

  • 1Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, Canada.

Journal of the International Federation of Clinical Chemistry
|May 7, 1996
PubMed
Summary

This review covers zinc, copper, and selenium, detailing their biological roles, metabolism, and clinical significance. It highlights conditions affecting trace element metabolism and provides pediatric reference ranges for accurate assessment.

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Area of Science:

  • Biochemistry
  • Clinical Medicine
  • Pediatrics

Background:

  • Essential trace elements like zinc, copper, and selenium play critical roles in human health.
  • Disturbances in trace element metabolism can lead to various clinical manifestations.
  • Accurate assessment of trace element status is crucial for diagnosis and management.

Purpose of the Study:

  • To review the biological functions, metabolism, and clinical implications of zinc, copper, and selenium.
  • To identify clinical scenarios associated with altered trace element metabolism.
  • To discuss key considerations for developing reliable trace element assays and provide pediatric reference ranges.

Main Methods:

  • Literature review of biological roles, metabolism, and clinical aspects of zinc, copper, and selenium.
  • Compilation of clinical situations and signs/symptoms related to trace element imbalances.
  • Analysis of critical factors in trace element assay development.

Main Results:

  • Detailed discussion on the functions and metabolic pathways of zinc, copper, and selenium.
  • Listing of clinical conditions and symptoms indicative of trace element deficiencies or toxicities.
  • Emphasis on the importance of assay validation and provision of pediatric reference data.

Conclusions:

  • Understanding the multifaceted roles of zinc, copper, and selenium is vital for clinical practice.
  • Recognizing signs of disturbed trace element metabolism aids in early diagnosis.
  • Standardized assays and appropriate reference ranges are essential for accurate pediatric trace element assessment.

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