Related Experiment Videos
An under-occluded roller pump is less hemolytic than a centrifugal pump
D J Rawn1, H K Harris, J B Riley
1Clinical Services Department, College of Health Professions, Medical University of South Carolina, Charleston, USA.
The Journal of Extra-Corporeal Technology
|February 6, 1997
Summary
Altering roller pump occlusion settings can significantly reduce hemolysis compared to centrifugal pumps. Opening roller pump occlusion settings results in lower index of hemolysis, offering a potential improvement in blood handling.
Area of Science:
- Biomedical Engineering
- Cardiovascular Devices
- Hemodynamics
Background:
- Hemolysis, the destruction of red blood cells, is a critical concern in cardiopulmonary bypass.
- Roller pumps (RP) and centrifugal pumps (CP) are commonly used, but their impact on hemolysis varies.
- Optimizing pump settings is essential to minimize blood trauma.
Purpose of the Study:
- To quantify and compare the hemolysis generated by roller pumps at various occlusion levels against a centrifugal pump.
- To test the hypothesis that different roller pump occlusion settings and centrifugal pumps produce similar levels of hemolysis.
Main Methods:
- Five identical closed-loop circuits were established, each with a different pump configuration: a centrifugal pump and a roller pump at four distinct occlusion settings.
- Circuits were primed with bovine blood, and pumps operated at a consistent flow rate (4.5 L/min) and afterload (250 mmHg) for three hours.
- Index of Hemolysis (IH) was measured and compared across all configurations using ANOVA.
Main Results:
- Under-occluded roller pump settings produced significantly lower Index of Hemolysis (IH) compared to the centrifugal pump.
- The centrifugal pump did not show a significantly greater IH than the roller pump set to a barely non-occlusive setting.
- Adjusting roller pump occlusion settings appears to be a viable method for reducing blood damage.
Conclusions:
- Modifying roller pump occlusion settings, particularly reducing occlusion, can lead to a lower Index of Hemolysis (IH) than traditional settings or centrifugal pumping.
- This suggests that roller pumps, when adjusted appropriately, may offer advantages in minimizing blood trauma during extracorporeal circulation.
- Further investigation into optimal roller pump parameters is warranted to enhance hemocompatibility.