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A poly-HEMA based aqueous humor draining device.

C T Chiang1, F J Liou, G C Niu

  • 1Institute of Biomedical Engineering, National Yang-Ming Medical College, Taipei, Taiwan.

Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials
|January 1, 1990
PubMed
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Poly(2-hydroxyethyl methacrylate) (poly-HEMA) shows promise as a biomaterial for aqueous humor draining devices. This implant effectively reduced intraocular pressure in rabbits for 250 days without blockage.

Area of Science:

  • Ophthalmology
  • Biomaterials Science
  • Glaucoma Research

Background:

  • Glaucoma management often requires surgical intervention to reduce intraocular pressure.
  • Existing aqueous humor draining devices face challenges such as biocompatibility and long-term patency.
  • Poly(2-hydroxyethyl methacrylate) (poly-HEMA) is a potential biomaterial for ophthalmic implants.

Purpose of the Study:

  • To evaluate the biocompatibility and functional longevity of a poly-HEMA aqueous humor draining device.
  • To assess the in vivo performance of poly-HEMA in a rabbit glaucoma model.

Main Methods:

  • A poly-HEMA draining device, similar in size to the Krupin tube, was fabricated.
  • In vitro testing with rabbit aqueous humor was performed to observe surface interactions.

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  • The device was implanted into rabbit eyes, and its function was monitored for 250 days.
  • Scanning Electron Microscopy (SEM) was used to analyze the retrieved device.

    • Main Results:

    • In vitro studies showed deposits on the poly-HEMA surface upon contact with aqueous humor.
    • A fibrous structure, likely proteinaceous, formed on the implant surface within 15 days.
    • The poly-HEMA draining device remained functional for 250 days post-implantation.
    • SEM analysis confirmed that the device's lumen remained unblocked.

    Conclusions:

    • Poly-HEMA demonstrates biocompatibility and sustained functionality as a material for aqueous humor draining devices.
    • The material shows potential for long-term use in glaucoma treatment by relieving intraocular pressure.
    • Further long-term studies are warranted to confirm the clinical applicability of poly-HEMA implants.