Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Cardiopulmonary bypass surgery.

J R Utley1

  • 1Spartanburg Regional Medical Center, Spartanburg, South Carolina.

Current Opinion in Cardiology
|April 1, 1992
PubMed
Summary
This summary is machine-generated.

Cardiopulmonary bypass (heart-lung machine) research highlights safe low-flow strategies and favors the alpha-stat blood gas method. It also details complications like choreoathetosis and adverse effects on blood cells.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Evaluation of the Hemochron 8000 Rx/Dx system for heparin management.

The journal of extra-corporeal technology·1997
Same author

The future of medical device development in the United States.

ASAIO journal (American Society for Artificial Internal Organs : 1992)·1997
Same author

Smoking is not a predictor of mortality and morbidity following coronary artery bypass grafting.

Journal of cardiac surgery·1996
Same author

Anger, patients, families, and risk management.

Journal of cardiac surgery·1996
Same author

The history of the concept of inflammatory responses to cardiopulmonary bypass.

Perfusion·1996
Same author

Coronary bypass in women.

The Annals of thoracic surgery·1996
Same journal

An integrative approach to patient selection for mitral transcatheter edge-to-edge repair in secondary mitral regurgitation.

Current opinion in cardiology·2026
Same journal

Rebooting blood vessel repair: implications of the SEMA-VR CardioLink-15 trial.

Current opinion in cardiology·2026
Same journal

Advancements in wearable technology for heart failure patients.

Current opinion in cardiology·2026
Same journal

Minimally invasive approaches to coronary artery bypass grafting: techniques, current evidence, and future directions.

Current opinion in cardiology·2026
Same journal

Advances in artificial intelligence for the evaluation of mitral regurgitation.

Current opinion in cardiology·2026
Same journal

Role of nutritional interventions to reduce cardiometabolic disease burden in the community.

Current opinion in cardiology·2026
See all related articles

Area of Science:

  • Cardiovascular Surgery
  • Anesthesiology
  • Critical Care Medicine

Background:

  • Cardiopulmonary bypass (CPB) is crucial for cardiac surgery but associated with complications.
  • Ongoing research addresses CPB-related issues across multiple scientific disciplines.

Purpose of the Study:

  • To synthesize new information on CPB, focusing on organ perfusion, blood gas management, and adverse effects.
  • To evaluate the safety and efficacy of different CPB strategies and identify associated risks.

Main Methods:

  • Review of current investigations on cardiopulmonary bypass.
  • Analysis of studies examining organ perfusion (brain, kidney) under varying flow and pressure conditions.
  • Evaluation of blood gas management schemes (pH-stat vs. alpha-stat) and hypothermia effects.

Related Experiment Videos

Main Results:

  • Low flow and pressure during CPB are safe when combined with hemodilution and hypothermia.
  • The alpha-stat blood gas scheme is favored over pH-stat, though findings can be inconclusive.
  • Low hypothermia levels are linked to choreoathetosis in pediatric patients.
  • CPB adversely affects platelets, leukocytes, and the complement system.
  • Minimum activated clotting time during CPB may be below 400 seconds.

Conclusions:

  • Optimized CPB management involves careful control of flow, pressure, temperature, and blood gas parameters.
  • Understanding CPB's systemic effects is vital for mitigating complications and improving patient outcomes.
  • Further research is needed to fully elucidate CPB's impact on hematologic parameters and neurological complications.