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Tricalcium phosphate as a bone graft substitute.

¹Department of Surgery, University of Toronto, Ontario, Canada.

Contemporary Orthopaedics

|October 5, 1992

Summary

Tricalcium phosphate bone filler is generally absorbed and replaced by host bone within six months. This clinical trial indicates tricalcium phosphate is a useful, resorbable material for bone void filling.

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Area of Science:

Biomaterials Science
Orthopedic Surgery
Regenerative Medicine

Background:

Tricalcium phosphate (TCP) is a synthetic biomaterial investigated for bone regeneration.
Understanding the resorption and replacement timeline of TCP is crucial for clinical applications.

Purpose of the Study:

To determine the in vivo timeframe for tricalcium phosphate resorption and replacement by host bone.
To evaluate the safety and efficacy of tricalcium phosphate as a bone filler in orthopedic procedures.

Main Methods:

A prospective clinical trial involving 20 patients undergoing total knee replacement.
Implantation of 8.5mm by 3mm tricalcium phosphate discs into the tibial surface.
Radiographic follow-up to assess material presence and bone integration.

Main Results:

Tricalcium phosphate discs were generally not identifiable radiographically at six months post-implantation.
No adverse effects were observed in patients at the two-year follow-up.
Complete incorporation and replacement by host bone were indicated by the absence of residual material.

Conclusions:

Tricalcium phosphate serves as an effective resorbable bone filler material.
The material demonstrates excellent biocompatibility and integration with host bone.
TCP shows promise for bone void filling in orthopedic surgery.

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