Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention01:05

Bioavailability Enhancement: Drug Stability Enhancement and GI Retention

120
Body:Improving a drug's stability in the gastrointestinal (GI) tract is paramount for enhancing its bioavailability and therapeutic effectiveness. Various strategies are employed to protect the drug from the harsh gastric milieu and to ensure its release and absorption at the desired site within the GI tract.Polymer coatings are one such method used to shield drugs from the stomach's acidic environment. By preventing premature drug release, these coatings improve the bioavailability of unstable...
120
Types of Step-Growth Polymers: Polyesters01:20

Types of Step-Growth Polymers: Polyesters

2.5K
The introduction of polyesters has brought major development to the textile industry. The wrinkle-free behavior of polyester blends has eliminated the need for starching and ironing clothes.
Polyesters are commonly prepared from terephthalic acid and ethylene glycol; the crude product is known as poly(ethylene terephthalate) or PET. However, polyesters are synthesized industrially by transesterification of dimethyl terephthalate with ethylene glycol at 150 °C. The two reactants and the polymer...
2.5K
Polymer Classification: Architecture01:14

Polymer Classification: Architecture

3.6K
Polymers are classified as linear or branched on the basis of their chain architecture. The polymer chains in linear polymers have a long chain-like structure with minimal to no branching at all. Even if a polymer features large substituent groups on the monomer, which appear as branches to the skeleton, it is not considered a branched polymer. A branched polymer contains secondary polymer chains that arise from the main polymer chain. The branching occurs when the polymer growth shifts from...
3.6K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Examining the Diagnostic Accuracy of a Novel Performance-Based Test for Alzheimer's Disease Screening.

The journal of prevention of Alzheimer's disease..·2024
Same author

Juvenile idiopathic arthritis and future risk for cardiovascular disease: a multicenter study.

Scandinavian journal of rheumatology·2016
Same author

Genome-wide association study identifies HLA 8.1 ancestral haplotype alleles as major genetic risk factors for myositis phenotypes.

Genes and immunity·2015
Same author

Use of atorvastatin in systemic lupus erythematosus in children and adolescents.

Arthritis and rheumatism·2011
Same author

Laboratory markers of cardiovascular risk in pediatric SLE: the APPLE baseline cohort.

Lupus·2010
Same author

The Cutaneous Assessment Tool: development and reliability in juvenile idiopathic inflammatory myopathy.

Rheumatology (Oxford, England)·2007
Same journal

Safer arterial access.

Medical device technology·2010
Same journal

Building better surfaces.

Medical device technology·2010
Same journal

PVC: a broader perspective.

Medical device technology·2010
Same journal

Joining and forming using torsional ultrasonic principles.

Medical device technology·2010
Same journal

US regulation of combination products.

Medical device technology·2010
Same journal

Assessing biological safety of metals associated with medical devices.

Medical device technology·2010
See all related articles

Related Experiment Video

Updated: Dec 13, 2025

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.0K

Biostable polyurethane elastomers.

M Szycher1, A M Reed

  • 1PolyMedica Industries, Inc., Woburn, Massachusetts 01801.

Medical Device Technology
|October 5, 1992
PubMed
Summary
This summary is machine-generated.

Researchers developed a new ether-free polyurethane, overcoming the microcracking issues common in current biomedical polyurethanes. This innovation enhances material stability for medical device applications.

More Related Videos

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

11.0K
Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
08:50

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

10.5K

Related Experiment Videos

Last Updated: Dec 13, 2025

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application
11:49

Synthesis of Soft Polysiloxane-urea Elastomers for Intraocular Lens Application

Published on: March 8, 2019

13.0K
Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization
08:02

Thin Film Composite Silicon Elastomers for Cell Culture and Skin Applications: Manufacturing and Characterization

Published on: July 3, 2018

11.0K
Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
08:50

Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces

Published on: September 26, 2014

10.5K

Area of Science:

  • Biomaterials Science
  • Polymer Chemistry

Background:

  • Polyurethanes are versatile synthetic polymers widely used in biomedical applications due to their favorable properties and biocompatibility.
  • However, in vivo implantation can lead to rapid microcracking, compromising structural integrity and promoting thrombus formation.

Purpose of the Study:

  • To develop and evaluate a novel ether-free polyurethane designed to resist surface microcracking under physiological conditions.
  • To address the limitations of conventional polyurethanes in long-term biomedical applications.

Main Methods:

  • Synthesis of a new ether-free polyurethane formulation.
  • Accelerated in vivo testing to assess material stability and microcracking resistance.
  • Microscopic analysis to evaluate surface integrity post-implantation.

Main Results:

  • The newly developed ether-free polyurethane demonstrated significant resistance to surface microcracking.
  • Unlike conventional polyurethanes, the novel material maintained structural integrity under accelerated in vivo conditions.
  • Absence of microcracking suggests reduced potential for thrombus formation and catastrophic failure.

Conclusions:

  • The ether-free polyurethane represents a promising advancement in biomaterials, offering enhanced stability for medical implants.
  • This material overcomes a critical failure mode of traditional polyurethanes, potentially improving the longevity and safety of biomedical devices.