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Related Experiment Videos

Plasticization of biodegradable polymers for use in controlled release.

A G Andreopoulos1

  • 1Department of Chemical Engineering, National Technical University of Athens, Zografos, Greece.

Clinical Materials
|December 9, 1993
PubMed
Summary

Researchers developed a biodegradable polymer for controlled drug release. Plasticized poly(DL-lactic acid) with 1,2-propylene glycol offers easier processing and enhanced early drug delivery, potentially improving treatments requiring high initial doses.

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Area of Science:

  • Polymer Science
  • Materials Science
  • Biomedical Engineering

Background:

  • Biodegradable polymers are crucial for drug delivery systems.
  • Poly(DL-lactic acid) is a common biodegradable polymer.
  • Plasticization can modify polymer properties for improved processing and drug release.

Purpose of the Study:

  • To design a plasticized, biodegradable polymer for controlled release.
  • To evaluate the compatibility of plasticizers with poly(DL-lactic acid).
  • To assess the impact of plasticization on processing temperature and drug release kinetics.

Main Methods:

  • Plasticization of poly(DL-lactic acid) oligomer using 1,2-propylene glycol and glycerol.
  • Compatibility testing of plasticizers with the polymer.

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  • Evaluation of processing temperature depression.
  • In vitro assessment of salicylic acid release from the prepared polymer mixtures.

    • Main Results:

    • 1,2-propylene glycol showed good compatibility with poly(DL-lactic acid) up to high concentrations.
    • Glycerol exhibited poor compatibility with the polymer.
    • Plasticized mixtures exhibited reduced processing temperatures.
    • Enhanced early-stage release of salicylic acid was observed.

    Conclusions:

    • 1,2-propylene glycol is a suitable plasticizer for poly(DL-lactic acid) in controlled-release applications.
    • The developed material allows for safe and easy processing, suitable for injection.
    • The system offers potential for controlled drug delivery with an initial high-dose release profile.