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Related Experiment Videos

Processing and characterization of absorbable polylactide polymers for use in surgical implants.

K P Andriano1, T Pohjonen, P Törmälä

  • 1Biomaterials Laboratory, Institute of Plastics Technology, Tampere University of Technology, Finland.

Journal of Applied Biomaterials : an Official Journal of the Society for Biomaterials
|July 1, 1994
PubMed
Summary

New poly(L/D-lactide) stereocopolymer fibers offer tunable degradation for absorbable surgical implants. These materials provide intermediate wet strength retention, bridging the gap between poly(glycolide) and poly(L-lactide) for tissue regeneration applications.

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Area of Science:

  • Biomaterials Science
  • Polymer Chemistry
  • Tissue Engineering

Background:

  • Absorbable fibers like poly(glycolide) (PGA) and poly(L-lactide) (PLLA) are used as scaffolds for tissue regeneration.
  • PGA degrades too quickly, while PLLA degrades too slowly for some surgical applications.
  • Copolymerization of L-lactide with D-lactide offers a potential solution for tailored degradation rates.

Purpose of the Study:

  • To investigate poly(L/D-lactide) stereocopolymers as absorbable fiber-based implant materials.
  • To evaluate the mechanical properties, crystallinity, and in vitro degradation of these novel fibers.
  • To determine their suitability for surgical applications in tissue repair and regeneration.

Main Methods:

  • Synthesis of poly(L/D-lactide) stereocopolymers with varying L/D lactide molar ratios (95/5, 90/10, 85/15).

Related Experiment Videos

  • Melt-spinning and hot-drawing of fibers, followed by mechanical testing, differential scanning calorimetry, birefringence, and X-ray diffraction.
  • In vitro degradation studies using pH 7.4 phosphate-buffered saline at 37°C to assess wet strength retention.

    • Main Results:

    • Fiber fabrication was reproducible.
    • Tensile strength, modulus, and birefringence increased with draw ratio up to 6.7, then declined.
    • Elongation to failure decreased across all draw ratios.
    • Fibers with a draw ratio of 6.7 showed a 10% difference in crystallinity between 90/10 and 85/15 ratios.
    • Wet strength retention after 12 weeks was ~10% for 90/10 and ~30% for 85/15 fibers.

    Conclusions:

    • Poly(L/D-lactide) stereocopolymer fibers demonstrate tunable mechanical properties and degradation rates.
    • The intermediate wet strength retention makes these materials promising for absorbable surgical implants.
    • These novel fibers could be valuable for tissue repair and regeneration applications, offering an alternative to existing PGA and PLLA materials.