[Structuro-functional parallels in several liver lesions in rats resulting from dietary protein deficiency]

The authors examined 60 white rats of the Wistar strain with initial age of four monts and weight of 200 -- 15 gm, subjected to deficient food regime with varous protein content (5.74%, 11.48%, but the control was 17.50% of protein) for a period of 16 weeks. After this period half of the animals were stimulated by an antigen -- 10% of human gamma globulin. They determined total protein and protein fractions in serum, histological changes in liver and some morphometric indices. It was established that there was a correlation between the level of serum proteins and the observed changes in liver parenchyma and mesenchyma, in which the factor "protein deficit" had significantly greater effect than the factor "heterologous serum protein" as an antigenic stimulus.