Anti-adhesive surfaces through hyaluronan coatings

The ability to resist adhesion of proteins, bacteria, cells and tissue is an important requirement for the surfaces of medical devices. This article describes a surface-modification process that imparts anti-adhesive properties to the surfaces of biomedical materials through the covalent binding of hyaluronan. It can be applied to a wide range of materials to yield anti-adhesive surfaces on plastics, metals and ceramics.