Current methods for the preparation of platelet concentrates: laboratory and clinical aspects

Modern blood transfusion services are striving to attain the highest standards through continual quality improvement and ensure that a formalised quality system is in place in the organisation for time management and waste reduction. With respect to the production of platelet concentrates (PCs), semi-automated and automated procedures are now available which are convenient and allow the processing of multiple packs simultaneously or the production of multiple doses of PCs with low leucocyte content. Nevertheless, PCs are highly heterogeneous on the basis of cellular content and storage stability. Statistical process control (SPC) is essential to ensure that optimal quality is maintained. In the light of new developments in platelet production, their clinical effect should be reappraised. This article highlights some of the key features in the production of PCs, focusing on basic concepts and quality indicators which reflect in vivo functions. The potential for bacteriological contamination and future production strategies are briefly mentioned.