Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Dendritic cells: therapeutic potentials.

J Banchereau1

  • 1Schering-Plough, Laboratory for Immunological Research, Dardilly, France.

Transfusion Science
|May 7, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

In vitro Activation of B-CLL Cells.

Leukemia & lymphoma·2016
Same author

Functional diversity of human vaginal APC subsets in directing T-cell responses.

Mucosal immunology·2012
Same author

Dendritic cells and immunity against cancer.

Journal of internal medicine·2010
Same author

Assessing oncologic benefit in clinical trials of immunotherapy agents.

Annals of oncology : official journal of the European Society for Medical Oncology·2010
Same author

Dendritic cells as melanoma vaccines.

Developments in biologicals·2004
Same author

Induction of dendritic cell differentiation by IFN-alpha in systemic lupus erythematosus.

Science (New York, N.Y.)·2001
Same journal

Discontinuous automated calcium supplementation during thrombocytapheresis with the haemonetics MCS+ version C.

Transfusion science·2002
Same journal

Is Brazil entering a new age?

Transfusion science·2001
Same journal

Is Brazil entering a new age?

Transfusion science·2001
Same journal

Post-transfusion thrombocytopenia in recipients with anti-HLA antibody.

Transfusion science·2000
Same journal

The design and properties of 3-hydroxypyridin-4-one iron chelators with high pFe(3+) values.

Transfusion science·2000
Same journal

A relationship between glucose metabolism and NO-mediated iron mobilization from cells.

Transfusion science·2000
See all related articles

Dendritic cells (DCs) are immune cells that initiate T-cell responses and can be generated in large numbers. DC therapy shows promise for treating cancer, infectious diseases, and potentially aiding organ transplantation.

Area of Science:

  • Immunology
  • Cell Biology

Background:

  • Dendritic cells (DCs) are critical leukocytes for initiating T-cell-mediated immune responses.
  • Immature DCs capture antigens, migrate to lymphoid organs, and mature to prime immune responses.
  • DCs are known as 'nature's adjuvant' due to their ability to prime immune responses without additional adjuvants.

Purpose of the Study:

  • To explore the potential of dendritic cells (DCs) in therapeutic applications.
  • To highlight the generation and function of DCs for immune modulation.
  • To discuss the role of DCs in cancer, infectious diseases, and transplantation.

Main Methods:

  • Generation of large numbers of DCs from monocytes or CD34 hematopoietic progenitors using GM-CSF with IL4 or TNF alpha.
  • In vivo studies in mice demonstrating the effects of tumor antigen-loaded DCs.

Related Experiment Videos

Main Results:

  • Tumor antigen-loaded DCs prevented tumor development and induced regression of established tumors in mice.
  • DCs can be generated ex vivo for therapeutic purposes.
  • DC populations capable of inducing tolerance have been identified.

Conclusions:

  • Dendritic cell therapy is a promising approach for cancer and infectious disease treatment.
  • DCs have potential applications in inducing tolerance for organ transplantation.
  • Further research into DC biology and therapy is warranted.