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Related Experiment Videos

The red cell storage lesion and its implication for transfusion.

I Chin-Yee1, N Arya, M S d'Almeida

  • 1Department of Haematology, London Health Sciences Centre, University of Western Ontario, Canada. icyee@lhsc.on.ca

Transfusion Science
|August 5, 1997
PubMed
Summary

Red blood cell storage causes detrimental changes, known as the storage lesion, affecting cell integrity and accumulating harmful substances. These alterations may impact patient outcomes following red blood cell transfusion.

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Area of Science:

  • Hematology
  • Transfusion Medicine
  • Biochemistry

Background:

  • Red blood cell (RBC) storage in preservative solutions leads to a complex set of changes termed the "storage lesion."
  • This lesion encompasses alterations within the erythrocytes themselves and the accumulation of bioactive molecules in the storage medium.
  • Understanding these changes is crucial for optimizing transfusion safety and efficacy.

Purpose of the Study:

  • To review the evidence regarding metabolic, biochemical, and molecular changes in stored red blood cells.
  • To discuss the accumulation of bioreactive substances during red blood cell storage.
  • To explore the potential clinical implications of the red blood cell storage lesion for transfusion recipients.

Main Methods:

  • Literature review of studies investigating red blood cell storage.

Related Experiment Videos

  • Analysis of biochemical and molecular alterations in erythrocytes and storage media.
  • Synthesis of evidence on the clinical impact of storage-related changes.

    • Main Results:

    • Storage induces significant metabolic, biochemical, and molecular damage to red blood cells.
    • Bioreactive substances, including cytokines and lipids, increase in concentration within the storage medium.
    • These cumulative changes constitute the "storage lesion" phenomenon.

    Conclusions:

    • The red blood cell storage lesion involves both cellular injury and the release of harmful substances.
    • Accumulated changes during storage may have significant clinical implications for patients receiving red blood cell transfusions.
    • Further research is warranted to mitigate the adverse effects of the storage lesion.