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Related Experiment Videos

An alternative method for evaluating lipoprotein(a) excess in plasma.

N G Song1, W Q Yang, C J Wang

  • 1Clinical Laboratory Department, No. 255 Hospital, PLA, Tangshan, Hebei, China.

Clinical Laboratory Science : Journal of the American Society for Medical Technology
|October 4, 1997
PubMed
Summary

Lipoprotein(a) cholesterol assays reliably measure lipoprotein(a) excess in patients with chronic renal failure, coronary heart disease, and cerebral infarction. This cholesterol measurement can substitute for lipoprotein(a) mass assays in clinical settings.

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Area of Science:

  • Clinical Chemistry
  • Cardiovascular Diagnostics
  • Biomarker Analysis

Background:

  • Elevated lipoprotein(a) [Lp(a)] is a risk factor for cardiovascular diseases.
  • Accurate measurement of Lp(a) is crucial for risk assessment.
  • Assessing Lp(a) excess can be challenging with current methods.

Purpose of the Study:

  • To evaluate the reliability of lipoprotein(a) cholesterol (Lp(a)-C) as an alternative to Lp(a) mass measurement.
  • To explore the utility of Lp(a)-C assay for detecting Lp(a) excess in various patient groups.

Main Methods:

  • Analyzed 396 plasma samples from healthy controls and patients with chronic renal failure, coronary heart disease, and cerebral infarction.
  • Measured both Lp(a)-C and Lp(a) mass using standard clinical chemistry kits.

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  • Performed linear regression analysis to correlate Lp(a)-C and Lp(a) mass in the control group.

    • Main Results:

    • Lp(a)-C and Lp(a) mass were significantly elevated in all patient groups compared to controls (P < 0.05 or P < 0.01).
    • A very high correlation (r = 0.9932) was observed between Lp(a)-C and Lp(a) mass in healthy individuals.
    • No significant differences in Lp(a) levels were found among the diseased groups.

    Conclusions:

    • Lp(a)-C assay is a stable and reliable method for assessing Lp(a) excess.
    • Lp(a)-C measurement can serve as a viable alternative to Lp(a) mass assays for patient evaluation.
    • Further research is warranted to elucidate the underlying mechanisms linking Lp(a)-C and Lp(a) levels.