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Protein A-immunoadsorption in chemotherapy associated hemolytic-uremic syndrome
E J Borghardt1, E J Kirchertz, I Marten
1Department of Hematology/Oncology (Tumor-Center Hanover), Germany.
Transfusion Science
|February 6, 1998
Abstract:
Circulating IgG-immune complexes (IgG-IC) play a role in the complex etiology of C-HUS. In an ongoing open clinical study protein A immunoadsorption treatment is carried out for patients who developed severe forms of the syndrome after mitomycin-C chemotherapy. So far, successful treatment of 14 out of 19 evaluable patients was possible. A protein A immunoadsorption system was used, allowing processing of large plasma volumes to eliminate IgG and IgG-IC from the patient's plasma.