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Related Experiment Videos

Carrageenan and dextran in rats.

R E Anderson, P J Warne, G B West

    International Archives of Allergy and Applied Immunology
    |January 1, 1976
    PubMed
    Summary

    Carrageenan injection causes inflammation in rat paws, preventing a reaction to a second dose. Dextran, however, does not alter subsequent responses, suggesting a cross-over technique improves drug testing.

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    Area of Science:

    • Pharmacology and Toxicology
    • Inflammation Research

    Background:

    • Carrageenan and dextran are commonly used agents to induce inflammation in animal models.
    • Understanding the specific inflammatory responses to these agents is crucial for preclinical drug evaluation.

    Purpose of the Study:

    • To investigate the cross-desensitization effects of carrageenan and dextran-induced inflammation in rat paws.
    • To evaluate the utility of a cross-over experimental design for anti-inflammatory drug testing.

    Main Methods:

    • Subcutaneous injection of carrageenan into one hindpaw of rats.
    • Subsequent challenge with carrageenan or dextran after 14 days.
    • Assessment of inflammatory response in the injected paw.
    • Comparison with dextran-induced inflammation and cross-over design.

    Main Results:

    • Carrageenan injection induced an anaphylactoid reaction, leading to desensitization of the paw to a second carrageenan dose.
    • Carrageenan injection did not affect the response to a subsequent dextran challenge.
    • Dextran injection did not alter the response to subsequent challenges with either dextran or carrageenan.
    • The cross-over technique, utilizing both paws, offers enhanced data for anti-inflammatory drug screening.

    Conclusions:

    • Carrageenan induces a specific desensitization, while dextran does not exhibit cross-desensitization.
    • A cross-over design in inflammation models provides more comprehensive data for evaluating anti-inflammatory drug efficacy.

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