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Life events before myocardial infarction.

J Connolly

    Journal of Human Stress
    |December 1, 1976
    PubMed
    Summary

    Recent life events, particularly those beyond personal control, were significantly more common in men preceding myocardial infarction (heart attack). This suggests a potential link between stressful life events and heart attack onset.

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    Area of Science:

    • Cardiology
    • Psychosomatic Medicine
    • Epidemiology

    Background:

    • Myocardial infarction (heart attack) is a leading cause of mortality.
    • The role of psychosocial factors, such as life events, in heart attack etiology is under investigation.
    • Previous studies suggest a correlation between stressful life events and cardiovascular events.

    Purpose of the Study:

    • To investigate the association between recent life events and the occurrence of myocardial infarction.
    • To determine if specific types of life events (controllable vs. uncontrollable) are more strongly linked to heart attack.

    Main Methods:

    • A case-control study involving 91 men who had myocardial infarction and 91 matched controls from an industrial workforce.
    • Participants were interviewed within days of admission to a Coronary Care Unit.
    • Life events experienced in the three months prior to myocardial infarction were assessed.

    Main Results:

    • Patients with myocardial infarction reported significantly more life events in the three weeks before infarction compared to controls (p < .01).
    • Uncontrollable life events were reported more frequently by patients both in the 12 weeks prior (p < .01) and the three weeks immediately before infarction (p < .02).
    • The association remained significant even when considering acute or anginal settings.

    Conclusions:

    • Recent life events, especially those perceived as uncontrollable, are significantly associated with myocardial infarction.
    • These findings suggest a potential role for stress and life events in the pathophysiology of heart attacks.
    • Methodological limitations warrant caution in definitively establishing causality.

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