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Related Experiment Videos

Complications associated with posterior staphyloma.

R C Pruett1

  • 1Schepens Retina Associates, Boston, MA 02114, USA.

Current Opinion in Ophthalmology
|May 7, 1998
PubMed
Summary

Severe myopia and posterior staphyloma can lead to legal blindness, with apoptosis playing a role. Early detection of functional changes in the macula is possible through electrophysiologic and psychophysiologic methods.

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Area of Science:

  • Ophthalmology
  • Genetics
  • Molecular Biology

Background:

  • Progressive myopia and posterior staphyloma are significant risk factors for legal blindness.
  • Programmed photoreceptor cell death (apoptosis) contributes to vision loss in some cases.
  • Macular abnormalities can precede clinically apparent lesions, detectable by functional tests.

Purpose of the Study:

  • To explore the mechanisms and detection of vision loss in myopia with posterior staphyloma.
  • To investigate the role of choroidal neovascularization and potential treatments.
  • To review current and emerging surgical techniques for severe myopia.

Main Methods:

  • Utilized electrophysiologic and psychophysiologic techniques for functional abnormality detection.
  • Employed Indocyanine green angiography to study macular choroidal neovascularization.
  • Reviewed experimental myopia modeling and clinical investigations of refractive surgeries.

Main Results:

  • Macular choroidal neovascularization is more prevalent in moderate staphyloma compared to advanced posterior pole atrophy.
  • Increased posterior choroidal drainage systems correlate with neovascularization.
  • Surgical extirpation of neovascular networks shows potential benefit, but scleroplasty's role is unclear.

Conclusions:

  • Early functional detection of macular changes in myopia is crucial.
  • Understanding choroidal neovascularization in staphyloma is key for management.
  • Novel surgical approaches are being investigated for severe myopia treatment.

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