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Related Experiment Videos

Intact PTH study: shipping frozen vs. unfrozen samples.

B L Gasser1, K J Mcdonald, V T O'Kain

  • 1DCI Laboratory, Nashville, TN 37204, USA.

Clinical Laboratory Science : Journal of the American Society for Medical Technology
|June 6, 1998
PubMed
Summary

Renal dialysis patients' lab results are comparable whether samples are frozen or unfrozen if analyzed within 24 hours. This finding allows clinics to ship unfrozen samples, improving logistical efficiency for parathyroid hormone (PTH) testing.

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Area of Science:

  • Clinical Chemistry
  • Laboratory Medicine
  • Renal Dialysis

Background:

  • Accurate parathyroid hormone (PTH) testing is crucial for managing renal dialysis patients.
  • Sample handling and storage protocols can impact laboratory test results.
  • Current protocols often require freezing of samples for PTH analysis, posing logistical challenges.

Purpose of the Study:

  • To compare the accuracy of PTH results from frozen versus unfrozen samples in renal dialysis patients.
  • To determine the stability of PTH levels in unfrozen samples over time.

Main Methods:

  • DCI Laboratory compared results using the INCSTAR N-tact PTH SP Kit.
  • Samples from renal dialysis patients were analyzed in both frozen and unfrozen states.
  • Unfrozen samples were tested at 24, 48, and 72 hours post-collection.

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Main Results:

  • No statistically significant or clinically relevant differences were observed between frozen and unfrozen samples analyzed within 24 hours.
  • PTH levels remained stable in unfrozen samples for up to 24 hours post-collection.

Conclusions:

  • Unfrozen samples are suitable for PTH analysis in renal dialysis patients if received and processed within 24 hours.
  • Clinics can now ship unfrozen samples, potentially streamlining laboratory workflows and reducing costs.
  • This finding supports optimized sample transport logistics for PTH testing in dialysis settings.