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Updated: Aug 11, 2026

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Published on: September 9, 2012
Familial primary cryofibrinogenemia
A J van Geest1, R J van Dooren-Greebe, M P Andriessen
1Department of Dermatology, TweeSteden Hospital, Tilburg, The Netherlands.
Background:
To our best knowledge this is the second case ever described of familial primary cryofibrinogenemia (CFG).
Patients:
A 29-year-old Moroccan female and two of her three children suffered from painful purpura, slow healing small ulcerations and edema of both feet during the winter season. Laboratory investigations revealed the presence of cryofibrinogen in their blood plasma. All three patients were otherwise healthy and no associated disease could be demonstrated.
Conclusions:
The diagnosis of CFG has to be considered in patients with livedo reticularis, edema, painful purpura and slow healing ulcera after cold exposure. Cryofibrinogen-precipitates in the blood plasma have to be determined. Because secondary CFG occurs much more frequently than the primary form, it is important to rule out associated diseases through extensive physical examination and laboratory investigations. This communication also stresses the importance of a through family history of patients with CFG. An autosomal dominant mode of inheritance is supposed.
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