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HPV 18-induced pigmented bowenoid papulosis of the neck
J M Baron1, A Rübben, E I Grussendorf-Conen
1Department of Dermatology, University Hospital RWTH Aachen, Germany.
Abstract:
We describe the case of a 53-year-old man in whom pigmented bowenoid papulosis developed on the skin of the neck. By polymerase chain reaction with general primers for genital human papillomaviruses (HPV) and subsequent restriction enzyme cleavage we could demonstrate HPV 18-related DNA in two biopsy specimens of the pigmented papules. To our knowledge, this report represents the first case of HPV 18-induced extragenital bowenoid papulosis of the neck.
Insights
This study reports the first case of human papillomavirus (HPV) 18 causing extragenital pigmented bowenoid papulosis on a man's neck. HPV 18 DNA was detected in skin biopsy samples.
Area of Science:
- Dermatology
- Virology
- Oncology
Background:
- Pigmented bowenoid papulosis is a rare, premalignant skin condition.
- Genital human papillomaviruses (HPV) are commonly associated with this condition, typically in anogenital areas.
Observation:
- A 53-year-old man presented with pigmented papules on his neck.
- Biopsy specimens of the lesions were analyzed.
Findings:
- Polymerase chain reaction (PCR) detected HPV 18-related DNA in the neck lesions.
- This is the first documented case of HPV 18-induced extragenital bowenoid papulosis on the neck.
Implications:
- This finding expands the known clinical spectrum of HPV 18.
- Highlights the potential for extragenital manifestations of HPV-related skin conditions.
- Suggests the need for considering HPV in the differential diagnosis of neck lesions.