Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Intrinsic myocardial function in hemorrhagic shock.

K H McDonough1, M Giaimo, M Quinn

  • 1Department of Physiology, Louisiana State University Medical Center, New Orleans 70112, USA.

Shock (Augusta, Ga.)
|April 3, 1999
PubMed
Summary

Hemorrhagic shock impacts cardiovascular function. Guinea pig hearts maintained normal function for up to 2 hours of shock, but function declined after 3 hours, indicating a loss of cardiac reserve.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Mechanisms of glucose intolerance in cystic fibrosis.

Diabetic medicine : a journal of the British Diabetic Association·2009
Same author

Urinary tract infection after stroke.

QJM : monthly journal of the Association of Physicians·2009
Same author

Connexin-specific cell-to-cell transfer of short interfering RNA by gap junctions.

The Journal of physiology·2005
Same author

E-mentoring: does it have a place in medicine?

Postgraduate medical journal·2005
Same author

Renal impairment in cystic fibrosis patients due to repeated intravenous aminoglycoside use.

Pediatric pulmonology·2004
Same author

High-resolution record of Northern Hemisphere climate extending into the last interglacial period.

Nature·2004

Area of Science:

  • Cardiovascular Physiology
  • Hemorrhagic Shock Research

Background:

  • Hemorrhage poses a significant stress to the cardiovascular system, reducing cardiac preload and blood pressure.
  • The heart's response involves sympathetic activation and altered preload/afterload dynamics.
  • The capacity of the heart to maintain contractile function during prolonged hemorrhagic shock remains unclear.

Purpose of the Study:

  • To investigate the effects of varying durations of hemorrhagic shock on intrinsic cardiac contractile function.
  • To determine the threshold at which prolonged hemorrhagic shock impairs myocardial function.

Main Methods:

  • Guinea pigs underwent surgical preparation for hemodynamic monitoring (blood pressure, heart rate, cardiac output).
  • Fifty percent of blood volume was removed to induce hemorrhagic shock.

Related Experiment Videos

  • Animals were observed for 1, 2, or 3 hours post-hemorrhage.
  • Cardiac function was assessed ex vivo after the shock period.

    • Main Results:

    • Hearts from animals subjected to 1 or 2 hours of hemorrhagic shock demonstrated normal ventricular function.
    • Hearts from animals exposed to 3 hours of hemorrhagic shock exhibited impaired ventricular function.
    • Metabolic indices indicated cardiovascular stress during shock.

    Conclusions:

    • The heart can maintain normal contractile function for up to 2 hours of hemorrhagic shock.
    • Prolonged shock (3 hours) leads to a disruption of the balance between myocardial oxygen demand and supply, resulting in loss of contractile reserve.
    • Adequate physiological modulation of coronary blood flow likely supports cardiac function during the initial 2 hours of shock.