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Multiple G-protein-coupled pathways inhibit N-type Ca channels of neurons
B Hille1, D J Beech, L Bernheim
1Department of Physiology and Biophysics, University of Washington, Seattle 98195, USA.
Life Sciences
|January 1, 1995
Abstract:
Muscarinic receptors depress Ca2+ currents in superior cervical ganglion neurons by two signaling pathways. One is sensitive to pertussis toxin and acts rapidly by a membrane-delimited pathway on the channels. The other is not sensitive to pertussis toxin and acts more slowly through an unknown second messenger. These pathways are shared with several other agonists.