Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Programmed cell death and the caspases.

G S Salvesen1

  • 1The Burnham Institute, La Jolla, California 92037, USA.

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
|April 6, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.

Cell death and differentiation·2014
Same author

Dying from within: granzyme B converts entosis to emperitosis.

Cell death and differentiation·2013
Same author

Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.

Cell death and differentiation·2012
Same author

Metacaspases are not caspases--always doubt.

Cell death and differentiation·2010
Same author

Enzymatically active single chain caspase-8 maintains T-cell survival during clonal expansion.

Cell death and differentiation·2010
Same author

Activation mechanism and substrate specificity of the Drosophila initiator caspase DRONC.

Cell death and differentiation·2008
Same journal

Immune Cell Composition and Prognosis in Node-Positive, Irradiated Breast Cancer Patients in the DBCG-IMN2 Study.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Urinary Secretory-IgA and IgG Responses and Inflammatory Markers in Patients With Pseudomonas aeruginosa Urinary Tract Infections.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Predictive Immunohistochemistry in Cholangiocarcinoma: Current Clinical Utility, Practical Limitations, and Emerging Directions.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

Active Chlorine Antiseptics in Wound Care: Recent Advances and Perspectives for Military Medicine.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

A Review on the Logistics, Financial, Ethical, and Regulatory Frameworks of Artificial Intelligence in Digital Pathology.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
Same journal

UE, CT, and ACR TI-RADS Grading in the Combined Diagnosis of Benign and Malignant Thyroid Nodules.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica·2026
See all related articles

Caspases are key regulators of apoptosis, or programmed cell death. Viruses and endogenous Inhibitor of Apoptosis Proteins (IAPs) have evolved to block caspases, controlling cell death pathways.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Background:

  • Caspases are critical cysteine proteases that execute apoptosis in animal cells.
  • Viral proteins have evolved to inhibit caspases, counteracting apoptosis during infection.
  • Endogenous Inhibitor of Apoptosis Proteins (IAPs) also regulate apoptosis by targeting caspases.

Purpose of the Study:

  • To elucidate the mechanisms by which viral and endogenous proteins modulate caspase activity.
  • To understand the role of caspases in initiating and executing programmed cell death.
  • To investigate the evolutionary adaptations of viruses to evade host apoptotic responses.

Main Methods:

  • Biochemical assays to measure caspase activity.
  • Protein interaction studies to identify binding partners.

Related Experiment Videos

  • Cell-based assays to assess apoptosis induction and inhibition.

    • Main Results:

    • Demonstration of viral proteins specifically blocking caspase function.
    • Identification of endogenous IAP proteins as direct caspase inhibitors.
    • Elucidation of IAPs' role in regulating apoptosis initiation and execution.

    Conclusions:

    • Caspase inhibition is a conserved strategy employed by both viruses and endogenous proteins to control apoptosis.
    • IAPs represent a crucial endogenous mechanism for fine-tuning programmed cell death.
    • Understanding these regulatory networks is vital for therapeutic interventions targeting cell death pathways.