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Ramipril reduces QT dispersion in patients with acute myocardial infarction and heart failure
K S Spargias1, S J Lindsay, A S Hall
1Institute for Cardiovascular Research, University of Leeds, United Kingdom.
Abstract:
In a cohort of 67 patients from the Acute Infarction Ramipril Efficacy study, we showed that ramipril therapy was associated with a significant reduction in QT dispersion over a 2-month period after acute myocardial infarction. This reduction of ventricular repolarization inhomogeneity indicates an antiarrhythmic effect and may be an important additional mechanism for the reduced all-cause mortality and sudden death incidence achieved with angiotensin-converting enzyme inhibition after acute myocardial infarction.
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