[Effectiveness of clomiphene treatment in anovulatory conditions]

The paper presents, the data on the treatment of 74 patients with anovular conditions varying by the pathogenesis, with klomiphen. Three groups of patients were distinguished depending on the therapeutic efficacy: the 1st group with a complete clinical effect, the 2nd group with a partial clinical effect, and the 3rd group - without any effect. In comparing the therapeutic efficacy with the data of gonadotropin examination it was revealed that the outcome of the therapy failed to depend on the initial LH and FSH level. However, there was revealed a reliable dependence of the therapeutic efficacy on the LH/FSH ratio: the nearer the LH/FSH ratio approached 1, the more effective was klomiphen therapy. Thus the LH/FSH ratio could be regarded as the criterion of choice of the patients for the klomiphen therapy, and could also be used for the prognostication of the results of treatment.