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Study of Calcium Dobesilate in Diabetic Rats
1Department of Pharmacology, School of Medicine, Complutense University, Madrid, Spain
Summary
Calcium dobesilate (DOBE) improved blood vessel function in diabetic rats by restoring endothelium-dependent relaxation and reducing contractile responses. This suggests DOBE may help prevent vascular complications associated with diabetes.
Area of Science:
- Vascular biology
- Pharmacology
- Diabetes research
Background:
- Vascular complications are a major cause of mortality in diabetic patients.
- Diabetic vasculature is susceptible to free radical damage, impairing relaxation.
- Calcium dobesilate (DOBE) is used for diabetic retinopathy.
Purpose of the Study:
- To investigate the in vivo and ex vitro effects of DOBE on aortic contractile and relaxing responses in diabetic rats.
- To assess DOBE's impact on endothelium-dependent and independent relaxation.
- To explore DOBE's influence on noradrenaline-induced contractions.
Main Methods:
- Used spontaneously diabetic rats (BB/wor) and control Wistar rats.
- Administered DOBE orally (50 and 500 mg/kg/day) to diabetic rats.
- Performed in vitro and ex vivo experiments on isolated thoracic aorta rings.
Main Results:
- In vitro, DOBE decreased noradrenaline-induced contraction and increased acetylcholine-induced endothelium-dependent relaxation.
- DOBE's effects on relaxation were endothelium-dependent, not affecting endothelium-independent relaxation.
- Ex vivo, DOBE treatment improved endothelium-dependent relaxation in diabetic rat arteries.
Conclusions:
- DOBE restores normal endothelium-dependent relaxation in spontaneously diabetic rats.
- DOBE reduces contractile responses to noradrenaline via beta-adrenergic receptors.
- DOBE shows potential in managing vascular dysfunction in diabetes.