Effects of saralasin on renal function of the rat

In the isolated perfused rat kidney, saralasin inhibits the vasoconstrictor effect of angiotensin II in a dose-dependent manner. At high infusion rates saralasin, by itself, increases renal vascular resistance and supresses renin release. Such an agonistic effect is not observed in the presence of high concentrations of angiotensin II. In acute renal failure induced by glycerol, saralasin has a beneficial effect on urine volume, solute excretion and plasma urea concentration only when it is administered together with an adequate volume of rat serum.