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[Corticoids and allergy].

C Delacourt1

  • 1Service de pneumologie et de pathologie professionnelle, centre hospitalier intercommunal de Créteil, France.

Archives De Pediatrie : Organe Officiel De La Societe Francaise De Pediatrie
|April 7, 1999
PubMed
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Corticosteroids prevent allergic reactions by targeting glucocorticoid receptors. These receptors modify inflammatory cell functions, notably inhibiting eosinophils, to reduce allergic inflammation.

Area of Science:

  • Immunology and Molecular Biology
  • Cellular and Molecular Pharmacology

Background:

  • Allergic reactions involve significant inflammation.
  • Corticosteroids are key in managing allergic responses, particularly the late phase.
  • The cellular mechanisms of corticosteroid action involve glucocorticoid receptors.

Purpose of the Study:

  • To elucidate the molecular mechanisms by which corticosteroids modulate allergic inflammation.
  • To detail the role of glucocorticoid receptors in regulating gene transcription and cellular function during allergic responses.
  • To investigate the impact of corticosteroids on inflammatory cells like eosinophils.

Main Methods:

  • Analysis of glucocorticoid receptor (GR) activation, dimerization, and nuclear translocation.
  • Investigation of GR binding to DNA and its effects on gene transcription (induction and repression).

Related Experiment Videos

  • Examination of GR interactions with transcription factors like AP-1 and NF-kappa B.
  • Assessment of corticosteroid effects on pro-inflammatory functions of eosinophils.

    • Main Results:

    • Glucocorticoid receptors, upon activation, translocate to the nucleus and influence gene expression.
    • Glucocorticosteroids modify cellular functions by altering transcription rates via GR.
    • GR interacts with key transcription factors (AP-1, NF-kappa B), modulating inflammatory pathways.
    • Corticosteroids effectively inhibit major pro-inflammatory functions of eosinophils.

    Conclusions:

    • Corticosteroids exert anti-inflammatory effects by modulating gene transcription through glucocorticoid receptors.
    • The interaction of glucocorticoid receptors with DNA and transcription factors is central to their anti-allergic action.
    • Corticosteroids play a crucial role in suppressing eosinophil-mediated inflammation in allergic reactions.