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Methylation of tea catechins by rat liver homogenates

K Okushio1, M Suzuki, N Matsumoto

  • 1Food Research Institute, Mitsui Norin Co. Ltd., Shizuoka, Japan.

Bioscience, Biotechnology, and Biochemistry
|April 8, 1999
PubMed

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Phase II Reactions: Methylation Reactions01:17

Phase II Reactions: Methylation Reactions

Methylation is a phase II biotransformation process involving the attachment of a methyl group to a substrate. Enzymes known as methyltransferases orchestrate this reaction.
The mechanism of methylation unfolds in two stages. The first stage sees a methyltransferase enzyme facilitating the transfer of a methyl group from S-adenosylmethionine (SAM) to the substrate, forming S-adenosylhomocysteine (SAH). The second stage involves further metabolism of SAH into homocysteine, which can be recycled...