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Interaction between capsaicin and nitrate tolerance in isolated guinea-pig heart
G Oroszi1, Z Szilvassy, J Nemeth
1Department of Pharmacology and Pharmacotherapy, Medical University of Pecs, Hungary. oroszi@apacs.pote.hu
European Journal of Pharmacology
|April 8, 1999
Abstract:
Capsaicin-induced increases in heart rate and coronary flow were blocked by N(G)-nitro-L-Arg-methyl ester (30 mM) in Langendorff-perfused guinea-pig hearts. Neither heart rate nor coronary flow changed by capsaicin in hearts from animals made tolerant to the hypotensive effect of 30 microg/kg nitroglycerin by the administration of 50 mg/kg nitroglycerin subcutaneously 4 times a day over 3 days. We conclude that the effector function of sensory nerves may deteriorate in nitrate tolerance.