Related Experiment Videos
Evidence for a polyclonal etiology of palmar fibromatosis
H A Chansky1, T E Trumble, E U Conrad
1Department of Orthopaedics, University of Washington School of Medicine, Seattle, USA.
The Journal of Hand Surgery
|April 8, 1999
Abstract:
X chromosome inactivation patterns at the androgen receptor locus were evaluated to determine clonality in microdissected lesional tissue and in leukocytes from 2 women with Dupuytren's disease. The tissue from both patients generated a polyclonal pattern of X chromosome inactivation of the human androgen receptor gene. This finding supports a polyclonal reactive process as the underlying etiology for palmar fibromatosis.