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Related Experiment Videos

Pathogenic neisseriae: complexity of pathogen-host cell interplay.

T F Meyer1

  • 1Max-Planck-Institut für Biologie, Tübingen, Germany. sinfbio@mpib-tuebingen.mpg.de

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
|April 8, 1999
PubMed
Summary

Neisserial adhesins like pili and Opa interact with host receptors, triggering cellular signaling pathways essential for bacterial colonization and immune response activation. This knowledge aids in developing new therapies for challenging bacterial infections.

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Area of Science:

  • Microbiology
  • Cellular Biology
  • Immunology

Background:

  • Neisserial adhesins, including pili and Opa proteins, mediate bacterial attachment to host cells.
  • These adhesins interact with host cell receptors such as heparan sulfate proteoglycans, CD66, and integrins.
  • Bacterial interactions trigger complex intracellular signaling cascades in host cells.

Purpose of the Study:

  • To elucidate the function of neisserial adhesins and their interaction with cellular receptors.
  • To understand the cellular signaling pathways activated by Neisseria infection.
  • To explore therapeutic strategies for bacterial infections based on signaling pathway knowledge.

Main Methods:

  • Analysis of neisserial adhesin function and receptor interactions.

Related Experiment Videos

  • Investigation of cellular signaling cascades in epithelial and phagocytic cells upon Neisseria infection.
  • Review of current and novel therapeutic interventions targeting these pathways.

    • Main Results:

    • Neisserial adhesins facilitate mucosal colonization by engaging specific host receptors.
    • Bacterial interactions activate signaling pathways involving phospholipase C, sphingomyelinase, protein kinase C, Src-related kinases, Rac1, p21-activated kinase, and Jun N-terminal kinase.
    • Activated pathways are crucial for bacterial entry and immune response induction, including cytokine release.

    Conclusions:

    • Understanding Neisseria-host cell signaling is key to combating bacterial infections.
    • Targeting these pathways offers potential for novel therapeutic and prophylactic strategies beyond antibiotics.
    • This research has implications for treating persistent and difficult-to-treat infections, such as periodontal disease.