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Dissolution kinetics evaluation of controlled-release tablets containing propranolol hydrochloride
M V Velasco-De-Paola1, M I Santoro, M N Gai
1Faculty of Pharmaceutical Sciences, University of São Paulo, Brasil.
Drug Development and Industrial Pharmacy
|April 9, 1999
Summary
Controlled-release propranolol hydrochloride tablets were developed for improved drug delivery. These formulations achieved more uniform drug levels in the plasma with twice-daily dosing.
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Propranolol hydrochloride is a widely used beta-blocker.
- Achieving uniform plasmatic levels is crucial for effective therapeutic outcomes.
- Existing formulations may require frequent administration, impacting patient compliance.
Purpose of the Study:
- To develop and characterize controlled-release propranolol hydrochloride tablets.
- To evaluate the drug release profile of the new formulation.
- To assess the suitability of the formulation for twice-daily administration.
Main Methods:
- Formulation of controlled-release tablets using hydrophobic Eudragit RSPO.
- Determination of the physical properties of the prepared tablets.
- In vitro dissolution testing of raw material and formulated tablets in various media (distilled water, simulated gastric juice, simulated enteric juice).
Main Results:
- The physical properties of the tablets were successfully determined.
- Dissolution tests indicated a controlled release pattern.
- The formulation demonstrated potential for achieving uniform drug levels.
Conclusions:
- Controlled-release propranolol hydrochloride tablets can be effectively prepared using Eudragit RSPO.
- The developed formulation shows promise for twice-daily administration, enhancing therapeutic efficacy.
- Further in vivo studies are warranted to confirm plasmatic level uniformity.