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Related Experiment Videos

Transfer insensitive labeling technique (TILT): application to multislice functional perfusion imaging.

X Golay1, M Stuber, K P Pruessmann

  • 1Institute of Biomedical Engineering and Medical Informatics, University of Zurich, Switzerland.

Journal of Magnetic Resonance Imaging : JMRI
|April 9, 1999
PubMed
Summary

This study demonstrates the TILT technique for mapping cerebral blood flow changes during motor tasks. The magnetization transfer insensitive labeling technique (TILT) effectively measures microvascular blood flow without artifacts.

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Area of Science:

  • Neuroimaging
  • Physiology
  • Medical Physics

Background:

  • Cerebral blood flow (CBF) is crucial for brain function.
  • Accurate measurement of microvascular CBF changes is challenging.
  • Existing techniques may suffer from artifacts like magnetization transfer.

Purpose of the Study:

  • To evaluate the TILT technique for multislice CBF mapping.
  • To assess microvascular blood flow changes during motor activation.
  • To quantify the spatial extent of activated brain areas.

Main Methods:

  • Utilized a novel perfusion sequence with water spin inversion as an endogenous tracer.
  • Employed the TILT technique, insensitive to magnetization transfer artifacts.
  • Perfusion mapping achieved by subtracting a perfusion-sensitized image from a control image.

Related Experiment Videos

  • Proximal blood labeling using two 90-degree radiofrequency excitation pulses.

    • Main Results:

    • Demonstrated TILT's capability for multislice CBF mapping.
    • Reported average perfusion signal changes of 36.9% (single-slice) and 38.1% (multislice) during activation.
    • Quantified activated brain volumes in motor and premotor areas.

    Conclusions:

    • TILT is a viable method for studying microvascular cerebral blood flow changes.
    • The technique is effective in both single and multislice modes.
    • Provides valuable data on blood flow dynamics during functional activation.