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New technologies for making vaccines.

R W Ellis1

  • 1BioChem Pharma, Inc., Northborough, MA, USA.

Vaccine
|April 9, 1999
PubMed
Summary
This summary is machine-generated.

This review explores major vaccine technologies, including live, subunit, and genetic approaches. It details criteria for selecting the most effective vaccine development strategies for diverse diseases.

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Area of Science:

  • Vaccinology
  • Immunology
  • Biotechnology

Background:

  • Active vaccine development encompasses live, subunit (killed/inactivated), and genetic technologies.
  • These categories include native microorganisms, recombinant antigens, and novel delivery systems/vectors.
  • Most diseases, infectious or noninfectious, can be targeted by multiple vaccine technologies.

Purpose of the Study:

  • To review major vaccine technologies.
  • To examine criteria for selecting optimal vaccine development strategies.
  • To provide examples of decision-making in vaccine research and development.

Main Methods:

  • Review of existing literature on vaccine technologies.
  • Analysis of decision-making criteria in vaccine development programs.

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  • Case examples illustrating the application of selection criteria.

    • Main Results:

    • Vaccine technologies are broadly categorized into live, subunit, and genetic platforms.
    • Selection of a vaccine technology depends on factors like pathogenesis, feasibility, immunobiology, efficacy, safety, and manufacturing.
    • A comprehensive approach considering all criteria is essential for successful R&D.

    Conclusions:

    • Effective vaccine development requires careful consideration of multiple technological platforms and selection criteria.
    • The choice of vaccine technology significantly impacts the success of R&D programs.
    • This review provides a framework for informed decision-making in vaccine development.