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Updated: Aug 16, 2026

Precision-cut Mouse Lung Slices to Visualize Live Pulmonary Dendritic Cells
Published on: April 5, 2017
[The lung as an immunologic organ]
1Klinische Abteilung für Pulmologie, IV. Medizinische Universitätsklinik Wien, Osterreich.
Abstract:
Immune response and restructuring of tissue during organ fibrosis mutually influence each other. It has become evident that the immunomodulatory properties of lining cells of the lung, such as bronchial or alveolar epithelial cells or pulmonary endothelial cells exert a major influence on the acute and chronic activation of the immune system. On the other hand, recent data obtained under in vivo conditions, suggest that the process of mesenchymal organ remodelling during inflammation not only causes organ fibrosis, but may actually perpetuate the process of chronic pulmonary inflammation due to its immunosuppressive effects. In this short review, two examples for this reciprocal influence are discussed.
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