Protein phosphatase 1 modulation of neostriatal AMPA channels: regulation by DARPP-32 and spinophilin
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Published on: August 13, 2017
Z Yan1, L Hsieh-Wilson, J Feng
1Laboratory of Molecular and Cellular Neuroscience, Rockefeller University, New York, New York 10021, USA.
Abstract:
Modulation of AMPA-type glutamate channels is important for synaptic plasticity. Here we provide physiological evidence that the activity of AMPA channels is regulated by protein phosphatase 1 (PP-1) in neostriatal neurons and identify two distinct molecular mechanisms of this regulation. One mechanism involves control of PP-1 catalytic activity by DARPP-32, a dopamine- and cAMP-regulated phosphoprotein highly enriched in neostriatum. The other involves binding of PP-1 to spinophilin, a protein that colocalizes PP-1 with AMPA receptors in postsynaptic densities. The results suggest that regulation of anchored PP-1 is important for AMPA-receptor-mediated synaptic transmission and plasticity.
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