Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Fertility patterns after appendicectomy: historical cohort study.

R Andersson1, M Lambe, R Bergström

  • 1Division of Surgery, University Hospital, Linköping, Sweden. roland.andersson@rhyov.vltjkpg.se

BMJ (Clinical Research Ed.)
|April 9, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Excess mortality for men and women above age 70 according to level of care during the first wave of COVID-19 pandemic in Sweden: A population-based study.

The Lancet regional health. Europe·2021
Same author

Determinants of non-adherence to adjuvant endocrine treatment in women with breast cancer: the role of comorbidity.

Breast cancer research and treatment·2018
Same author

Serum inflammatory markers in relation to prostate cancer severity and death in the Swedish AMORIS study.

International journal of cancer·2018
Same author

No increased prevalence of malignancies among first-degree relatives of 800 patients with chronic myeloid leukemia: a population-based study in Sweden.

Leukemia·2017
Same author

Increased prevalence of prior malignancies and autoimmune diseases in patients diagnosed with chronic myeloid leukemia.

Leukemia·2016
Same author

Small bowel obstruction: early parameters predicting the need for surgical intervention.

European journal of trauma and emergency surgery : official publication of the European Trauma Society·2016

Childhood appendectomy for a perforated appendix does not harm female fertility. However, women who had a normal appendix removed in childhood showed higher fertility rates than the general population.

Area of Science:

  • Reproductive Health
  • Surgical Outcomes
  • Pediatric Surgery

Background:

  • Appendicitis is common in children, and appendectomy is a frequent surgical procedure.
  • Concerns exist regarding potential long-term effects of appendectomy, particularly appendiceal perforation, on female fertility.
  • Understanding fertility outcomes after childhood appendectomy is crucial for clinical management and patient counseling.

Purpose of the Study:

  • To investigate the association between childhood appendectomy and subsequent female fertility patterns.
  • To compare fertility outcomes in women with perforated appendix, non-perforated appendix, and incidental appendectomy (normal appendix) versus a control group.

Main Methods:

  • A historical cohort study design was employed, utilizing computerized data.
Keywords:
BiologyDemographic FactorsDeveloped CountriesEuropeFertilityGastrointestinal EffectsNorthern EuropePhysiologyPopulationPopulation DynamicsResearch ReportScandinaviaSurgerySwedenTreatment

Related Experiment Videos

  • 9,840 women who underwent appendectomy before age 15 (1964-1983) were compared with 47,590 age-matched controls from the Swedish general population.
  • Fertility data, including age at first birth and parity, were analyzed using survival analysis methods and followed up to 1994.

    • Main Results:

    • Women with a history of perforated appendix showed fertility rates similar to controls (adjusted hazard ratio 0.95).
    • Women who underwent appendectomy for a normal appendix exhibited an increased rate of first births (1.48), earlier age at first birth, and higher parity compared to controls.
    • No significant long-term negative consequences on female fertility were observed following a perforated appendix in childhood.

    Conclusions:

    • Childhood appendectomy for a perforated appendix does not appear to negatively impact long-term female fertility.
    • The findings suggest that women with a normal appendix removed during childhood may represent a subgroup with inherently higher fertility.
    • These results have implications for surgical decision-making in pediatric appendicitis, potentially justifying exploratory surgery even with a lower suspicion of appendicitis.