Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Computer support for determining drug dose: systematic review and meta-analysis.

R Walton1, S Dovey, E Harvey

  • 1ICRF General Practice Research Group, University of Oxford, Department of Public Health and Primary Care, Institute of Health Sciences, Oxford OX3 7LF. robert.walton@public-health.oxford.ac.uk

BMJ (Clinical Research Ed.)
|April 9, 1999
PubMed
Summary

Computer-aided drug dosing in hospitals improves drug concentration and speeds up therapeutic control. This technology helps clinicians adjust medication doses accurately for individual patients, leading to fewer adverse effects.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Case Report: Successful management of bilateral ureteral obstruction following repair of iatrogenic urethral ligation and transection during a canine cryptorchidectomy.

Frontiers in veterinary science·2026
Same author

Preferences for Advanced Therapy Medicinal Products: Understanding the Published Literature on the Value of Innovative Health Interventions.

Inquiry : a journal of medical care organization, provision and financing·2025
Same author

Effectiveness and safety of menopause treatments: pitfalls of available evidence and future research need.

Climacteric : the journal of the International Menopause Society·2024
Same author

Conceptualizing a model for European health systems: the institutional framework.

Internal and emergency medicine·2023
Same author

Antidepressants Trial in Parkinson's Disease (ADepT-PD): protocol for a randomised placebo-controlled trial on the effectiveness of escitalopram and nortriptyline on depressive symptoms in Parkinson's disease.

BMC neurology·2022
Same author

An examination of bedtime media and excessive screen time by Canadian preschoolers during the COVID-19 pandemic.

BMC pediatrics·2022

Area of Science:

  • Pharmacology and Clinical Pharmacy
  • Medical Informatics

Background:

  • Optimizing drug dosage is critical for effective patient treatment.
  • Traditional dosing methods can lead to suboptimal drug concentrations and delayed therapeutic effects.
  • Computer support systems offer potential for improved accuracy in drug dose determination.

Purpose of the Study:

  • To systematically review the effectiveness of computer support systems in determining optimal drug doses.
  • To evaluate the impact of computer-assisted dosing on drug concentrations, time to therapeutic control, and treatment outcomes.

Main Methods:

  • Systematic review of comparative studies (1966-1996) involving computer-assisted drug dosing advice.
  • Inclusion of studies using individualized pharmacokinetic models for dose calculations.

Related Experiment Videos

  • Qualitative analysis of relative percentage differences and quantitative meta-analyses of effect sizes.

    • Main Results:

    • Eighteen studies involving drugs like theophylline, warfarin, and heparin met inclusion criteria.
    • Meta-analysis of 671 patients showed computer support led to higher drug blood concentrations (ES 0.69) and faster therapeutic control (ES 0.44).
    • Computer assistance resulted in fewer adverse effects, with five of six studies reporting improved outcomes.

    Conclusions:

    • Computer support for drug dose determination is beneficial in acute hospital settings.
    • These systems may enhance clinician confidence in adjusting doses for individual patient needs.
    • Further research is recommended to assess the benefits of computer-assisted dosing in general clinical practice.