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Influence of stimulation of the olivocerebellar pathway by harmaline on spatial learning in the rat
C Meignin1, P Hilber, J Caston
1UPRES PSY.CO 1780, Faculté des Sciences, Laboratoire de Neurobiologie de l'Apprentissage, Université de Rouen, 76821 Mont-Saint-Aignan Cedex, France.
Brain Research
|April 10, 1999
Abstract:
Administration of harmaline to the rat, which activates synchronously and rhythmically the olivary neurons and the olivocerebellar pathway, elicits visuo-motor, spatial learning and spatial memory deficiencies which are dose-dependent. Since activation and lesion of the olivocerebellar pathway have similar effects, it is concluded that normal functioning of this pathway is required for spatial learning achievement.