Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

High density lipoprotein: are elevated levels desirable and achievable?

C L Bisgaier1, M E Pape

  • 1Department of Vascular and Cardiac Diseases, Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Company, Ann Arbor, MI 48105, USA. Bisgaic@aa.wl.com

Current Pharmaceutical Design
|April 10, 1999
PubMed
Summary

Elevated high-density lipoprotein (HDL) levels are linked to reduced coronary heart disease (CHD) risk. This review explores strategies for developing HDL-raising therapies for hypoalphalipoproteinemia and CHD.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Discovering HDL-elevating drugs: are there simplistic approaches to a polygenic disorder?

IDrugs : the investigational drugs journal·2008
Same author

Long hydrocarbon chain diols and diacids with central ether or ketone moieties that favorably alter lipid disorders.

Die Pharmazie·2006
Same author

Dietary cholate increases plasma levels of apolipoprotein B in mice by posttranscriptional mechanisms.

The international journal of biochemistry & cell biology·2001
Same author

High-dose recombinant apolipoprotein A-I(milano) mobilizes tissue cholesterol and rapidly reduces plaque lipid and macrophage content in apolipoprotein e-deficient mice. Potential implications for acute plaque stabilization.

Circulation·2001
Same author

Expression of the mRNA encoding truncated PPAR alpha does not correlate with hepatic insensitivity to peroxisome proliferators.

Molecular and cellular biochemistry·2001
Same author

Rabbits possess a serum paraoxonase polymorphism similar to the human Q192R.

Pharmacogenetics·2001

Area of Science:

  • Cardiovascular Science
  • Lipid Metabolism
  • Pharmacology

Background:

  • High-density lipoprotein (HDL) plays a crucial role in reverse cholesterol transport.
  • The clinical significance of elevated HDL levels and strategies to increase HDL are areas of active research.

Purpose of the Study:

  • To evaluate if elevated HDL is a desirable clinical target for cardiovascular disease prevention.
  • To explore potential therapeutic strategies for increasing HDL levels.

Main Methods:

  • Review of human epidemiologic and prospective data on HDL and coronary heart disease (CHD).
  • Analysis of HDL structure, enzymatic features, and metabolic origins.
  • Examination of data from human mutations, animal models, and in vitro systems focusing on HDL metabolism.

Related Experiment Videos

  • Evaluation of existing and novel HDL-raising compounds and therapeutic approaches.

    • Main Results:

    • Epidemiologic data supports HDL as a protective factor against CHD.
    • Understanding HDL metabolism involves key plasma and cell-associated proteins.
    • Various strategies, including small molecules, gene therapy, and biologicals, are proposed for HDL elevation.

    Conclusions:

    • Elevated HDL is a desirable clinical endpoint for reducing CHD risk.
    • Promising agents and unconventional approaches exist for treating hypoalphalipoproteinemia and CHD by raising HDL.