Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Recent developments in tetracycline antibiotics.

P E Sum1, F W Sum, S J Projan

  • 1Wyeth-Ayerst Research, Pearl River, NY 10965, USA.

Current Pharmaceutical Design
|April 10, 1999
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

MgrA is a multiple regulator of two new efflux pumps in Staphylococcus aureus.

Journal of bacteriology·2005
Same author

Antibacterial drug discovery: is it all downhill from here?

Clinical microbiology and infection : the official publication of the European Society of Clinical Microbiology and Infectious Diseases·2004
Same author

Uses of Staphylococcus aureus GeneChips in genotyping and genetic composition analysis.

Journal of clinical microbiology·2004
Same author

Genome-wide transcriptional profiling of the response of Staphylococcus aureus to cell-wall-active antibiotics reveals a cell-wall-stress stimulon.

Microbiology (Reading, England)·2003
Same author

Global regulation of Staphylococcus aureus genes by Rot.

Journal of bacteriology·2003
Same author

In vitro and in vivo activities of tigecycline (GAR-936), daptomycin, and comparative antimicrobial agents against glycopeptide-intermediate Staphylococcus aureus and other resistant gram-positive pathogens.

Antimicrobial agents and chemotherapy·2002
Same journal

Role of Phenolic Nanocompounds in Inflammatory Disorders: Current View and Future Aspects.

Current pharmaceutical design·2026
Same journal

Overcoming Physiological Barriers in Brain Tumor Therapy: Advances in Nanomedicine, Ultramolecular Pharmaceuticals, and Targeted Drug Delivery.

Current pharmaceutical design·2026
Same journal

Breathing Life into Research: The Transformative Potential of Lung-on-a-Chip Technology.

Current pharmaceutical design·2026
Same journal

Cross-Tissue Transcriptome-Wide Association Study Prioritizes Candidate Genes and Compound-Associated Signatures for Osteoarthritis.

Current pharmaceutical design·2026
Same journal

Emerging Role of AI in Gastroenterology and Hepatology: Revolutionizing Medical Device-Assisted Diagnosis.

Current pharmaceutical design·2026
Same journal

Nanostructured Lipid Carriers in Drug Targeting: Characterization, Patents, and Recent Innovations.

Current pharmaceutical design·2026
See all related articles

New glycylcycline antibiotics show potent activity against drug-resistant bacteria, offering a promising solution to combat rising antibiotic resistance. These novel tetracycline derivatives are effective against Gram-positive and Gram-negative pathogens, including those resistant to other antibiotics.

Area of Science:

  • Microbiology
  • Pharmacology
  • Infectious Diseases

Background:

  • Rising antibiotic resistance, particularly to tetracyclines, poses a significant global health threat.
  • Existing antibiotics are becoming less effective against pathogenic bacteria.
  • There is an urgent need for novel antimicrobial agents to overcome resistance mechanisms.

Purpose of the Study:

  • To review recent advances in tetracycline research over the past two decades.
  • To elucidate mechanisms of bacterial resistance to tetracyclines.
  • To highlight the development and potential of novel tetracycline derivatives, focusing on glycylcyclines.

Main Methods:

  • Review of scientific literature on tetracycline derivatives and resistance mechanisms.
  • Analysis of semisynthetic approaches and fermentation-derived compounds.

Related Experiment Videos

  • Focus on glycylcycline derivatives, examining their in vitro and in vivo activity.

    • Main Results:

    • Identification of efflux inhibitors effective in in vitro models.
    • Glycylcyclines demonstrate potent broad-spectrum activity against Gram-positive and Gram-negative bacteria.
    • These derivatives are effective against strains with known tetracycline resistance mechanisms (efflux, ribosomal protection) and cross-resistance to other antibiotic classes.

    Conclusions:

    • Glycylcyclines represent a promising new class of tetracyclines with significant potential to combat antibiotic resistance.
    • Their broad spectrum of activity and effectiveness against resistant strains make them valuable candidates for clinical development.
    • Further research into structure-activity relationships and mode of action will optimize their therapeutic use.