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Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays
07:42

Assessment of Resistance to Tyrosine Kinase Inhibitors by an Interrogation of Signal Transduction Pathways by Antibody Arrays

Published on: September 19, 2018

The protein kinase ABC's of signal transduction as targets for drug development

R I Glazer1

  • 1Department of Pharmacology, Georgetown University Medical Center, Washington, DC 20007, USA. glazerr@gunet.georgetown.edu

Current Pharmaceutical Design
|April 10, 1999
PubMed

Insights

Signal transduction pathways regulate tumor growth and metastasis. Key serine/threonine-protein kinases like PKA, Akt, and PKC are crucial targets for novel cancer therapies, including structure-based drug design and antisense oligonucleotide therapy.

Area of Science:

  • Oncology
  • Molecular Biology
  • Biochemistry

Background:

  • Signal transduction pathways are critical for regulating tumor cell growth, survival, and metastasis.
  • Serine/threonine-protein kinases, including cyclic AMP-dependent protein kinase (PKA), Akt (PKB), and protein kinase C (PKC), are key regulators within these pathways.
  • Dysregulation of these kinases contributes to tumor proliferation, cell survival, and multidrug resistance.

Purpose of the Study:

  • To highlight the role of serine/threonine-protein kinases in cancer.
  • To explore the potential of these kinases as therapeutic targets for cancer treatment.
  • To discuss structure-based drug design and antisense oligonucleotide therapy approaches.

Main Methods:

  • Analysis of signal transduction pathways involved in cancer.
  • Review of crystallographic structures of key protein kinases.
  • Exploration of therapeutic strategies targeting protein kinases.

Main Results:

  • Protein kinases PKA, Akt, and PKC modulate critical cancer-related pathways.
  • Unique structural features of these kinases offer opportunities for targeted drug design.
  • Antisense oligonucleotide therapy targeting these kinases shows potential for selective cancer cell inhibition.

Conclusions:

  • Serine/threonine-protein kinases are vital targets for cancer drug development.
  • Structure-based drug design and antisense oligonucleotide therapy present promising strategies.
  • Targeting these kinases may lead to selective tumor growth inhibition and apoptosis induction with reduced side effects.

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