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Updated: Oct 23, 2026
An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
Identification of novel bladder tumour suppressor genes
1ICRF Cancer Medicine Research Unit, St. James's University Hospital, Leeds, UK. m.knowles@icrf.icnet.uk
Abstract:
Many genetic alterations have recently been identified in transitional cell carcinoma (TCC) of the bladder. These include alterations to known proto-oncogenes and tumour suppressor genes and the identification of multiple sites of nonrandom chromosomal deletion which are predicted to define the location of as yet unidentified tumour suppressor genes. This review summarises recent efforts to define the location of novel bladder tumour suppressor genes using loss of heterozygositiy (LOH) and homozygous deletion analyses and to isolate the genes targeted by these deletions. For three of the four regions of deletion on chromosome 9, the most frequently deleted chromosome in TCC, candidate genes have been identified. It is anticipated that the identification of the genes and/or genetic regions which are frequently altered in TCC will provide useful tools for diagnosis, prediction of prognosis, patient monitoring and novel therapies.
Insights
Researchers are identifying new bladder tumor suppressor genes in transitional cell carcinoma (TCC). These genetic discoveries in bladder cancer aim to improve diagnosis, prognosis, and treatment strategies.
Area of Science:
- Oncology
- Genetics
- Molecular Biology
Background:
- Transitional cell carcinoma (TCC) of the bladder is characterized by numerous genetic alterations.
- These alterations involve known oncogenes, tumor suppressor genes, and chromosomal deletions indicating novel tumor suppressor gene locations.
Purpose of the Study:
- To review recent advancements in pinpointing novel bladder tumor suppressor genes.
- To identify genes affected by chromosomal deletions in TCC.
Main Methods:
- Utilizing loss of heterozygosity (LOH) analysis.
- Employing homozygous deletion analyses.
- Investigating chromosomal deletions on chromosome 9, a frequently altered region in TCC.
Main Results:
- Several candidate genes have been identified within the deleted regions on chromosome 9.
- Three out of four deletion regions on chromosome 9 have associated candidate genes.
Conclusions:
- Identifying frequently altered genes and genetic regions in TCC is crucial.
- These findings are expected to aid in diagnosis, prognosis prediction, patient monitoring, and the development of novel therapies for bladder cancer.
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