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Comparison of lung-function reference values.

X Baur1, S Isringhausen-Bley, P Degens

  • 1Berufsgenossenschaftliches Forschungsinstitut für Arbeitsmedizin, Bochum, Germany.

International Archives of Occupational and Environmental Health
|April 10, 1999
PubMed
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Current lung function prediction equations may be outdated. This study found that while some spirometric values align with existing recommendations, others, particularly flow-volume curves and plethysmographic volumes, show significant discrepancies, suggesting a need for updated reference values.

Area of Science:

  • Pulmonary Medicine
  • Occupational Health
  • Epidemiology

Background:

  • Lung-function reference values are crucial for diagnosing occupational and environmental respiratory diseases.
  • Existing prediction equations, often over 20 years old, may not accurately reflect current population data.
  • Accurate lung function assessment is vital for medical surveillance, preventive measures, and disability benefits.

Purpose of the Study:

  • To evaluate the accuracy of current lung function prediction equations against a healthy control group.
  • To identify discrepancies in predicted versus measured lung function values.
  • To recommend updated or more appropriate reference equations for clinical use.

Main Methods:

  • Collected spirometric and plethysmographic lung function data (including T(LCO)) from 139 healthy subjects.

Related Experiment Videos

  • Calculated the differences between measured values and predicted values based on various established equations.
  • Analyzed standardized mean residuals and probabilities to assess agreement with different prediction models.

    • Main Results:

    • Forced Vital Capacity (FVC), Forced Expiratory Volume in 1 second (FEV1), and FEV1/FVC ratios showed good agreement with Crapo, Roca, Glindmeyer, Brändli, and Berger equations.
    • Significant deviations were observed in normative flow-volume curve parameters compared to the control group.
    • Plethysmographically measured lung volumes (FRC, TLC, RV) were poorly reflected by Quanjer's reference equations.
    • Diffusing capacity of the lung for carbon monoxide (T(LCO) and K(CO)) showed good agreement with Cotes' predictions for females but less so for males.

    Conclusions:

    • European Respiratory Society (ERS) values for FVC, FEV1, and FEV1/FVC require verification due to potential inaccuracies.
    • The formulas proposed by Brändli et al. are recommended for their better evaluation and applicability.
    • Extrapolation using Brändli et al.'s formulas is suggested for the 60-70 year age range pending new epidemiological data.