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Related Experiment Videos

Intersections between blood cell development and leukemia genes.

S H Orkin1, C Porcher, Y Fujiwara

  • 1Division of Hematology, Children's Hospital and the Dana Farber Cancer Center, Harvard Medical School and the Howard Hughes Medical Institute, Boston, Massachusetts 02115, USA. Orkin@rascal.med.harvard.edu

Cancer Research
|April 10, 1999
PubMed
Summary
This summary is machine-generated.

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Leukemia-associated transcription factors SCL/tal-1 and TEL are crucial for both blood cell development and blood vessel formation (angiogenesis). Gene targeting reveals their essential roles in hematopoietic lineages and yolk sac development.

Area of Science:

  • Hematology
  • Molecular Biology
  • Developmental Biology

Background:

  • Transcription factors regulate hematopoietic development and cell fate.
  • Leukemia-associated genes often have critical roles in normal blood cell development.
  • SCL/tal-1 and TEL are two such transcription factors implicated in leukemia.

Purpose of the Study:

  • To review gene-targeting experiments on SCL/tal-1 and TEL.
  • To elucidate the functions of these factors in blood cell and vessel development.
  • To highlight the intrinsic roles of leukemia-associated transcription factors.

Main Methods:

  • Review of gene-targeting experiments.
  • Analysis of SCL/tal-1 and TEL functions in hematopoietic development.
  • Investigation of roles in angiogenesis and bone marrow microenvironment.

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Main Results:

  • SCL/tal-1 is essential for all hematopoietic lineages and yolk sac angiogenesis.
  • TEL is required for yolk sac angiogenesis and establishment of hematopoiesis in bone marrow.
  • Both factors demonstrate dual functions in blood and vessel development.

Conclusions:

  • Leukemia-associated transcription factors play intrinsic roles in normal hematopoiesis.
  • SCL/tal-1 and TEL are critical for both blood cell formation and angiogenesis.
  • Understanding these factors provides insight into both development and leukemia.