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Ocular surface disease in atopic dermatitis.

M Dogru1, N Nakagawa, K Tetsumoto

  • 1Department of Ophthalmology, Kobe University School of Medicine, Japan.

Japanese Journal of Ophthalmology
|April 10, 1999
PubMed
Summary
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Severe active atopic dermatitis (AD) often causes ocular surface disorders, including lid eczema and keratoconjunctivitis. These conditions are linked to impaired tear film quantity and quality, necessitating careful eye examinations for AD patients.

Area of Science:

  • Ophthalmology
  • Dermatology
  • Immunology

Background:

  • Atopic dermatitis (AD) is a chronic inflammatory skin condition.
  • Ocular surface complications are common in patients with severe AD.

Purpose of the Study:

  • To investigate the prevalence and types of ocular surface disorders in patients with severe active atopic dermatitis.
  • To assess tear film function in this patient cohort.

Main Methods:

  • Ophthalmic examinations were performed on 362 patients with severe active AD.
  • Tear film break-up time (BUT) and Schirmer tests were utilized to evaluate tear function.

Main Results:

  • Lid eczema (65.7%) and superficial punctate keratopathy (67.5%) were the most frequent ocular findings.

Related Experiment Videos

  • Abnormal tear film break-up time (<10 seconds) was observed in 62.4% of eyes.
  • Reduced Schirmer test values (<5 mm) were noted in 56.2% of eyes, indicating tear deficiency.

    • Conclusions:

    • Ocular surface disorders are highly prevalent in severe active AD patients.
    • Impaired tear film quantity or quality, potentially due to allergic mechanisms, likely contributes to these ocular issues.
    • Regular and thorough ophthalmic examinations are crucial for managing AD patients.